Medications to Use With Caution When You're Sick

When you're sick—especially with a fever, stomach bug, or flu—it’s natural to reach for medications to help you feel better. But did you know that some common medications can actually make things worse when your body is already under stress?

Whether you're dealing with dehydration, low appetite, or fatigue, here are some medications you should use with caution when you're not feeling your best.

🩺 1. NSAIDs (Ibuprofen, Naproxen)

Examples: Advil®, Motrin®, Aleve®

Why to be cautious:These anti-inflammatory medications are often used for pain and fever but can irritate your stomach, raise blood pressure, and put extra strain on your kidneys—especially if you’re dehydrated or haven’t been eating well.

Better option:Try acetaminophen (Tylenol®), which is generally safer when you’re sick. Still, follow the dosing instructions carefully and avoid alcohol.

💧 2. Diuretics (Water Pills)

Examples: Hydrochlorothiazide (HCTZ), furosemide (Lasix®)

Why to be cautious:Diuretics help reduce blood pressure and fluid retention, but they also make you lose fluids and electrolytes. If you're already dehydrated due to vomiting, diarrhea, or fever, diuretics can make things worse—leading to dizziness, low blood pressure, and even kidney issues.

What to do:If you're feeling sick and not keeping fluids down, talk to your provider before continuing your diuretic. You may need to temporarily adjust the dose.

❤️ 3. ACE Inhibitors

Examples: Lisinopril, Enalapril, Ramipril

Why to be cautious:ACE inhibitors lower blood pressure and protect your heart and kidneys, but they can also affect how your body balances salt and fluid—especially during illness. When you’re sick and dehydrated, these medications may increase the risk of kidney injury and electrolyte imbalances (like high potassium).

What to watch for:If you're feeling lightheaded, weak, or not urinating normally, contact your provider. They may advise holding the medication temporarily.

😤 4. Decongestants (Pseudoephedrine, Phenylephrine)

Examples: Sudafed®, DayQuil®, Mucinex D®

Why to be cautious:Decongestants can help relieve nasal congestion, but they may also increase your heart rate and blood pressure and worsen anxiety or sleep issues—especially when your body is already stressed from illness.

Gentler options:Use saline nasal sprays, humidifiers, or warm steam to relieve sinus pressure naturally without affecting your cardiovascular system.

💊 5. Supplements & Herbal Remedies

Examples: Echinacea, Ginseng, St. John’s Wort, high-dose zinc or vitamin C

Why to be cautious:Even “natural” remedies can have side effects or interact with other medications. High doses of vitamins and certain herbs can stress your liver or kidneys, interfere with medications, or worsen nausea—especially when you’re sick.

Smart tip:Always let your provider know if you’re taking supplements, especially when you're not feeling well.

✅ When You're Sick, Keep It Simple

• Hydrate: Drink fluids often, especially with fever, vomiting, or diarrhea.

• Rest: Your body heals best when you’re well-rested.

• Eat light: Stick to bland, easy-to-digest foods.

• Check medications: Some may need to be paused—call your provider if unsure.

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Not Sure What’s Safe to Take?

We're here to help. Whether you're managing chronic conditions like high blood pressure or just trying to get through a cold, our team can help you safely navigate medications while you're sick.

📞 Call us today or schedule a telehealth appointment for guidance on how to adjust your medications when you're under the weather.